Project Sherlock

Life & Health Sciences

Medicine & Health

Clinical knowledge, public health and the evidence base underneath both — an area where bad information does measurable harm.

31 fields · 295 topics · 32 curated works

Fields within Medicine & Health

Human Anatomy & Physiology

11

The map and the mechanism, prerequisite to everything else.

Gross Anatomy · Histology · Musculoskeletal Anatomy · Neuroanatomy (Clinical) · Cardiovascular System

Internal Medicine & Diagnosis

8

The generalist's discipline — pattern recognition under uncertainty.

Clinical Reasoning · History & Physical Examination · Differential Diagnosis · Diagnostic Error · Multimorbidity

Cardiovascular Medicine

10

The leading cause of death worldwide.

Coronary Artery Disease · Heart Failure · Arrhythmias · Electrocardiography · Hypertension

Neurology & Neurosurgery

11

Disorders of the nervous system.

Stroke · Epilepsy · Multiple Sclerosis · Parkinson's Disease · Alzheimer's & Dementia

Oncology

11

Cancer biology and its treatment.

Cancer Biology & Hallmarks · Carcinogenesis · Tumour Staging · Chemotherapy · Radiation Oncology

Infectious Disease

11

Pathogens, transmission and control.

Bacterial Infections · Viral Infections · Fungal Infections · Parasitic Disease · Antimicrobial Therapy

Immunology & Rheumatology

8

When the immune system attacks the wrong target.

Rheumatoid Arthritis · Systemic Lupus Erythematosus · Vasculitis · Spondyloarthropathies · Gout & Crystal Arthropathy

Endocrinology & Metabolism

9

Hormonal regulation and its disorders.

Diabetes Mellitus · Insulin Resistance · Thyroid Disorders · Adrenal Disorders · Pituitary Disorders

Gastroenterology & Hepatology

9

The gut, the liver and everything they influence.

Inflammatory Bowel Disease · Irritable Bowel Syndrome · Peptic Ulcer Disease · Liver Disease & Cirrhosis · Viral Hepatitis

Respiratory Medicine

9

Airway, lung and gas exchange disorders.

Asthma · COPD · Pneumonia · Interstitial Lung Disease · Pulmonary Embolism

Nephrology & Urology

9

Kidney function, filtration and the urinary tract.

Acute Kidney Injury · Chronic Kidney Disease · Dialysis · Kidney Transplantation · Electrolyte Disorders

Surgery

11

Intervention with a scalpel, and the judgement of when not to.

Surgical Principles · General Surgery · Trauma Surgery · Vascular Surgery · Cardiothoracic Surgery

Emergency & Critical Care

10

Medicine under time pressure with incomplete information.

Triage · Resuscitation & ACLS · Shock · Sepsis · Trauma Management

Anaesthesiology & Pain Medicine

8

Controlled unconsciousness, and the management of pain.

General Anaesthesia · Regional Anaesthesia · Airway Management · Anaesthetic Pharmacology · Acute Pain Management

Paediatrics

8

Medicine for patients who are not small adults.

Neonatology · Child Development · Childhood Immunisation · Paediatric Infectious Disease · Congenital Disorders

Obstetrics & Gynaecology

9

Reproductive health, pregnancy and birth.

Antenatal Care · Labour & Delivery · Obstetric Complications · Maternal Mortality · Contraception

Psychiatry & Mental Health

13

Clinical treatment of mental illness.

Depressive Disorders · Anxiety Disorders · Bipolar Disorder · Schizophrenia & Psychosis · PTSD & Trauma

Dermatology

8

The largest organ, and the most visible diagnoses.

Eczema & Dermatitis · Psoriasis · Acne · Skin Infections · Skin Cancer

Ophthalmology & Otolaryngology

9

Eyes, ears, nose and throat.

Refractive Error · Cataract · Glaucoma · Retinal Disease · Hearing Loss

Musculoskeletal & Orthopaedics

9

Bones, joints, tendons and the injuries that limit people.

Fractures & Fixation · Joint Replacement · Sports Injuries · Back & Neck Pain · Osteoarthritis

Radiology & Medical Imaging

9

Seeing inside without opening.

Radiography · Computed Tomography · Magnetic Resonance Imaging · Ultrasound · Nuclear Medicine & PET

Pathology & Laboratory Medicine

10

Where diagnoses are confirmed.

General Pathology · Histopathology · Cytopathology · Clinical Chemistry · Haematology

Pharmacology & Therapeutics

10

What drugs do, and what they do that you did not want.

Pharmacokinetics · Pharmacodynamics · Drug Interactions · Adverse Drug Reactions · Drug Development Pipeline

Geriatrics & Palliative Care

9

Medicine near the end of life, where goals change.

Ageing Physiology · Frailty · Falls & Mobility · Cognitive Decline · Polypharmacy in the Elderly

Sports & Exercise Medicine

8

Performance, injury and the medicine of healthy bodies.

Exercise Prescription · Injury Prevention · Return to Play · Concussion in Sport · Strength & Conditioning Science

Nutrition Science

9

Food and health — a field with unusually noisy evidence.

Macronutrients · Micronutrients & Deficiency · Energy Balance · Dietary Patterns · Nutritional Epidemiology & Its Limits

Public Health & Epidemiology

12

Health at the level of populations rather than patients.

Study Design in Epidemiology · Disease Surveillance · Outbreak Investigation · Infectious Disease Modelling · Screening Programmes

Global Health

8

Health where resources are the binding constraint.

Maternal & Child Health · Neglected Tropical Diseases · Malaria · Water, Sanitation & Hygiene · Health Systems Strengthening

Evidence-Based Medicine

11

How to tell whether a medical claim is supported — the most transferable skill in this domain.

Levels of Evidence · Randomised Controlled Trials in Medicine · Systematic Review & Meta-Analysis · Number Needed to Treat · Absolute vs Relative Risk

Medical Ethics & Law

9

The rules that constrain clinical action.

Informed Consent · Patient Autonomy · Confidentiality · Resource Allocation & Triage Ethics · End-of-Life Decision Making

History of Medicine

9

How medicine became effective, mostly quite recently.

Ancient & Classical Medicine · Germ Theory · Antiseptic Surgery · Discovery of Antibiotics · Anaesthesia's Arrival

Reading in Medicine & Health

32

Start here

No prior grounding assumed.

  • The Noonday DemonAndrew Solomon, 2001

    Depression written from inside it and researched from outside it at once, refusing both the purely biological and purely social account.

    Book
  • Mountains Beyond MountainsTracy Kidder, 2003

    Paul Farmer's argument, in practice, that cost-effectiveness arguments are usually a way of deciding whose lives are worth less.

    Book
  • The Great InfluenzaJohn M. Barry, 2004

    The 1918 pandemic as a failure of institutions as much as of medicine — official reassurance killed people that the virus might not have.

    Book
  • Bad ScienceBen Goldacre, 2008

    Dissects how health claims get manufactured — from bad trials to worse journalism — and gives the tools to check them.

    Book
  • The Checklist ManifestoAtul Gawande, 2009

    In complex work, failure comes more often from ineptitude than ignorance, and a well-designed checklist closes that gap.

    Book
  • The Emperor of All MaladiesSiddhartha Mukherjee, 2010

    A biography of cancer that doubles as a history of how clinical evidence replaced physician intuition.

    Book
  • The Immortal Life of Henrietta LacksRebecca Skloot, 2010

    The cell line that built modern biology was taken without consent, and the family learned about it two decades later.

    Book
  • Testing TreatmentsEvans, Thornton, Chalmers & Glasziou, 2011· Free

    A plain-language guide to why fair tests of treatments are necessary and how to spot claims that lack them.

    Book
  • Do No HarmHenry Marsh, 2014

    A neurosurgeon on operating millimetres from someone's personality, and unusually honest about the cases he got wrong.

    Book
  • Being MortalAtul Gawande, 2014

    Medicine optimises for survival when patients near the end of life are usually optimising for something else entirely.

    Book
  • ImmunePhilipp Dettmer, 2021

    Makes the immune system followable as a system of interacting agents, which is the only way its complexity becomes learnable.

    Book

Then

Assumes you know the vocabulary.

  • On the Mode of Communication of CholeraJohn Snow, 1855

    Maps cholera deaths to a single water pump and establishes epidemiological reasoning before germ theory existed.

    Book
  • West's Respiratory Physiology: The EssentialsJohn B. West, 1974

    Compresses everything clinically necessary about breathing into a genuinely short book, and is the model for how a textbook can be brief.

    Book
  • Naked to the BoneBettyann Holtzmann Kevles, 1997

    A history of medical imaging from X-rays to MRI, and of how being able to see inside the body changed what counted as diagnosis.

    Book

Go deeper

Primary sources and full treatments.

  • Gray's AnatomyHenry Gray, 1858

    The anatomical reference in continuous revision for over a century and a half — still the map every surgeon is working from.

    Book
  • Goodman & Gilman's The Pharmacological Basis of TherapeuticsGoodman & Gilman, 1941

    The reference on what drugs actually do, at the level of receptor and pathway rather than indication.

    Book
  • Harrison's Principles of Internal MedicineHarrison et al., 1950

    Organises medicine by presenting problem rather than by organ, which is how a patient actually arrives.

    Book
  • Robbins and Cotran Pathologic Basis of DiseaseRobbins & Cotran, 1957

    Explains disease by mechanism rather than by symptom list, and is consequently the book that makes the rest of medicine cohere.

    Book
  • The Greatest Benefit to MankindRoy Porter, 1997

    A history of medicine that is candid about how recently most of it started working, and how much was confident harm before that.

    Book
  • Williams ObstetricsJ. Whitridge Williams et al., 1903

    In continuous revision for over a century, and a record of how maternal mortality was driven down by asepsis and measurement.

    Book
  • Nelson Textbook of PediatricsNelson et al., 1933

    The reference on patients who are not small adults — different physiology, different diseases, and a moving developmental baseline.

    Book
  • Campbell's Operative OrthopaedicsWillis C. Campbell et al., 1939

    The operative reference for the musculoskeletal system, where the goal is restored mechanical function rather than cure.

    Book
  • Williams Textbook of EndocrinologyWilliams et al., 1950

    The reference on the body's slow signalling system, where the feedback loops are the diagnosis.

    Book
  • Adler's Physiology of the EyeAdler et al., 1950

    The reference on the optics and neurology of vision, where the engineering constraints are unusually explicit.

    Book
  • Modern Nutrition in Health and DiseaseShils et al., 1955

    The reference text, and a useful corrective to a popular literature that runs far ahead of what the trials actually support.

    Book
  • Fitzpatrick's Dermatology in General MedicineFitzpatrick et al., 1971

    The reference on the one organ you can examine directly, and how often it is the first visible sign of an internal disease.

    Book
  • Sleisenger and Fordtran's Gastrointestinal and Liver DiseaseSleisenger & Fordtran, 1973

    The reference for the organ system that is simultaneously digestive, immune and endocrine, and rarely fails in only one of those ways.

    Book
  • Brenner and Rector's The KidneyBarry M. Brenner & Floyd C. Rector, 1976

    The reference on the organ that regulates nearly every parameter of the internal environment, and fails quietly until it fails completely.

    Book
  • Braunwald's Heart DiseaseEugene Braunwald, 1980

    The cardiology reference, and a record of the field that produced more mortality reduction than almost any other in medicine.

    Book
  • Miller's AnesthesiaRonald D. Miller, 1981

    The reference on deliberately suspending consciousness and reversing it, a procedure still not fully explained by the theory behind it.

    Book
  • Rosen's Emergency MedicineRosen et al., 1983

    The reference for decisions made without a history, without a diagnosis, and without time — a genuinely different epistemic problem.

    Book
  • Brukner & Khan's Clinical Sports MedicinePeter Brukner & Karim Khan, 1993

    The reference on injury in active people, organised by the body region that hurts rather than by the tissue that failed.

    Book