Testing Treatments
Evans, Thornton, Chalmers & Glasziou
A plain-language guide to why fair tests of treatments are necessary and how to spot claims that lack them.
link checked 17 Sept 2026Life & Health Sciences
Clinical knowledge, public health and the evidence beneath both — an area where bad information does measurable harm.
31 fields · 326 topics · 357 curated works
The map and the mechanism, prerequisite to everything else.
Foundations & Overviews · Gross Anatomy · Histology · Musculoskeletal Anatomy · Neuroanatomy (Clinical)
The generalist's discipline — pattern recognition under uncertainty.
Foundations & Overviews · Clinical Reasoning · History & Physical Examination · Differential Diagnosis · Diagnostic Error
The leading cause of death worldwide.
Foundations & Overviews · Coronary Artery Disease · Heart Failure · Arrhythmias · Electrocardiography
Disorders of the nervous system — stroke, epilepsy and dementia, where localising the lesion is half the work.
Foundations & Overviews · Stroke · Epilepsy · Multiple Sclerosis · Parkinson's Disease
Cancer biology and its treatment — the hallmarks, staging, and the shift from cytotoxic to targeted therapy.
Foundations & Overviews · Cancer Biology & Hallmarks · Carcinogenesis · Tumour Staging · Chemotherapy
Pathogens, transmission and control.
Foundations & Overviews · Bacterial Infections · Viral Infections · Fungal Infections · Parasitic Disease
When the immune system attacks the wrong target.
Foundations & Overviews · Rheumatoid Arthritis · Systemic Lupus Erythematosus · Vasculitis · Spondyloarthropathies
Hormonal regulation and its disorders.
Foundations & Overviews · Diabetes Mellitus · Insulin Resistance · Thyroid Disorders · Adrenal Disorders
The gut, the liver and everything they influence.
Foundations & Overviews · Inflammatory Bowel Disease · Irritable Bowel Syndrome · Peptic Ulcer Disease · Liver Disease & Cirrhosis
Airway, lung and gas exchange disorders.
Foundations & Overviews · Asthma · COPD · Pneumonia · Interstitial Lung Disease
Kidney function, filtration and the urinary tract.
Foundations & Overviews · Acute Kidney Injury · Chronic Kidney Disease · Dialysis · Kidney Transplantation
Intervention with a scalpel, and the judgement of when not to.
Foundations & Overviews · Surgical Principles · General Surgery · Trauma Surgery · Vascular Surgery
Medicine under time pressure with incomplete information.
Foundations & Overviews · Triage · Resuscitation & ACLS · Shock · Sepsis
Controlled unconsciousness, and the management of pain.
Foundations & Overviews · General Anaesthesia · Regional Anaesthesia · Airway Management · Anaesthetic Pharmacology
Medicine for patients who are not small adults.
Foundations & Overviews · Neonatology · Child Development · Childhood Immunisation · Paediatric Infectious Disease
Reproductive health, pregnancy and birth.
Foundations & Overviews · Antenatal Care · Labour & Delivery · Obstetric Complications · Maternal Mortality
Clinical treatment of mental illness.
Foundations & Overviews · Depressive Disorders · Anxiety Disorders · Bipolar Disorder · Schizophrenia & Psychosis
The largest organ, and the most visible diagnoses.
Foundations & Overviews · Eczema & Dermatitis · Psoriasis · Acne · Skin Infections
Eyes, ears, nose and throat — the specialties of the special senses, where small structures carry large consequence.
Foundations & Overviews · Refractive Error · Cataract · Glaucoma · Retinal Disease
Bones, joints, tendons and the injuries that limit people.
Foundations & Overviews · Fractures & Fixation · Joint Replacement · Sports Injuries · Back & Neck Pain
Seeing inside without opening — radiography, CT, MRI and ultrasound, and the reading that turns signal into diagnosis.
Foundations & Overviews · Radiography · Computed Tomography · Magnetic Resonance Imaging · Ultrasound
Where diagnoses are confirmed — histology, clinical chemistry and molecular tests, underneath most clinical decisions.
Foundations & Overviews · General Pathology · Histopathology · Cytopathology · Clinical Chemistry
What drugs do, and what they do that you did not want.
Foundations & Overviews · Pharmacokinetics · Pharmacodynamics · Drug Interactions · Adverse Drug Reactions
Medicine near the end of life, where goals change.
Foundations & Overviews · Ageing Physiology · Frailty · Falls & Mobility · Cognitive Decline
Performance, injury and the medicine of healthy bodies.
Foundations & Overviews · Exercise Prescription · Injury Prevention · Return to Play · Concussion in Sport
Food and health — a field with unusually noisy evidence.
Foundations & Overviews · Macronutrients · Micronutrients & Deficiency · Energy Balance · Dietary Patterns
Health at the level of populations rather than patients.
Foundations & Overviews · Study Design in Epidemiology · Disease Surveillance · Outbreak Investigation · Infectious Disease Modelling
Health where resources are the binding constraint.
Foundations & Overviews · Maternal & Child Health · Neglected Tropical Diseases · Malaria · Water, Sanitation & Hygiene
How to tell whether a medical claim is supported — the most transferable skill in this domain.
Foundations & Overviews · Levels of Evidence · Randomised Controlled Trials in Medicine · Systematic Review & Meta-Analysis · Number Needed to Treat
The rules that constrain clinical action.
Foundations & Overviews · Informed Consent · Patient Autonomy · Confidentiality · Resource Allocation & Triage Ethics
How medicine became effective, mostly quite recently.
Foundations & Overviews · Ancient & Classical Medicine · Germ Theory · Antiseptic Surgery · Discovery of Antibiotics
No prior grounding assumed.
Testing Treatments
Evans, Thornton, Chalmers & Glasziou · 2011
A plain-language guide to why fair tests of treatments are necessary and how to spot claims that lack them.
+71 more at this level
Assumes you know the vocabulary.
On the Mode of Communication of Cholera
John Snow · 1855
Maps cholera deaths to a single water pump and establishes epidemiological reasoning before germ theory existed.
+129 more at this level
Primary sources and full treatments.
De Humani Corporis Fabrica
Andreas Vesalius · 1543
Rebuilt anatomy on direct human dissection rather than Galen's animal-based authority, correcting a long list of errors that had gone unquestioned…
+154 more at this level
12 of 357 works
Evans, Thornton, Chalmers & Glasziou
A plain-language guide to why fair tests of treatments are necessary and how to spot claims that lack them.
link checked 17 Sept 2026James Parkinson
Describes six cases of a tremor-and-rigidity syndrome he calls paralysis agitans, isolating it as a distinct disease from the general palsies it had previously been lumped with.
link checked 17 Sept 2026William Osler
Collects addresses urging 'equanimity' — calm, unshaken judgement — as the essential professional temperament for physicians, alongside Osler's own more contentious argument that a doctor's most productive years end by sixty.
link checked 17 Sept 2026F. H. A. Marshall
Surveys reproductive physiology across species as a single comparative science, giving the field its first systematic textbook treatment and establishing the concept of the oestrous cycle.
link failing as of 17 Sept 2026Nuremberg Military Tribunal
Sets out ten conditions for ethical human experimentation, beginning with voluntary consent, written in direct response to the medical experiments prosecuted at Nuremberg.
link checked 17 Sept 2026Basil I. Hirschowitz, Larry E. Curtiss, C. Wilbur Peters & Herbert M. Pollard
Describes the first flexible fiberoptic gastroscope, replacing rigid instruments and making direct visual examination of the entire stomach practical for the first time.
Surgeon General's Advisory Committee on Smoking and Health
Reviews the accumulated pathological and epidemiological evidence to conclude officially that cigarette smoking causes lung cancer, triggering the first wave of American tobacco-control policy.
link checked 17 Sept 2026World Medical Association
Sets out ethical principles for medical research on human subjects, distinguishing therapeutic from non-therapeutic research and requiring free informed consent, extending the Nuremberg Code into ongoing professional self-regulation.
link checked 17 Sept 2026Elisabeth Kübler-Ross
Argues, from interviews with dying patients, that dying follows a recognisable psychological sequence — denial, anger, bargaining, depression, acceptance — and that clinicians who ignore it fail their patients at the end of life.
Tuskegee Syphilis Study Ad Hoc Advisory Panel
Concludes that a forty-year study of untreated syphilis in Black men was ethically unjustified from its start, that subjects were denied treatment and informed consent throughout, and recommends federal rules to prevent a repeat.
link checked 17 Sept 2026World Health Organization
Introduces the concept of a limited national list of essential medicines chosen for proven efficacy, safety and comparative cost, arguing that most health systems could meet the great majority of their populations' needs with a few hundred well-chosen drugs rather than the tens of thousands on the market.
link checked 17 Sept 2026International Conference on Primary Health Care
Declares primary health care, not hospital-centred specialist medicine, the route to health for all, and commits governments to it as a matter of social justice.
link checked 17 Sept 2026