Project Sherlock

Medicine & Health · Pathology & Laboratory Medicine

Molecular Diagnostics

A topic within Pathology & Laboratory Medicine, itself one of 11 topics in that field and part of Medicine & Health.

Reading on Molecular Diagnostics

2

2 works

Lecture1993

The Polymerase Chain Reaction

Kary B. Mullis

Mullis's own Nobel lecture account of conceiving PCR, arguing the technique's power lies in its conceptual simplicity — repeated cycles of a simple reaction — rather than any single clever reagent, and tracing how that simplicity was initially underestimated.

link checked 17 Sept 2026
Paper1985

Enzymatic Amplification of Beta-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

Randall K. Saiki, Stephen Scharf, Fred Faloona, Kary B. Mullis, Glenn T. Horn, Henry A. Erlich & Norman Arnheim

Demonstrates that a targeted DNA sequence can be enzymatically copied a millionfold before testing for a disease-causing mutation, introducing the polymerase chain reaction as a practical basis for molecular diagnosis.

link checked 17 Sept 2026