Neuroscience · Clinical & Applied Neuroscience
A topic within Clinical & Applied Neuroscience, itself one of 10 topics in that field and part of Neuroscience.
2 works
Hardy & Higgins
Proposes that deposition of amyloid beta protein is the initiating event in Alzheimer's disease, with neurofibrillary tangles, cell loss and dementia following as downstream consequences.
Selkoe & Hardy
Revisits the amyloid cascade hypothesis after twenty-five years, defending its core logic while acknowledging that amyloid accumulation alone does not explain the timing or severity of Alzheimer's dementia.
link checked 17 Sept 2026