Neuroscience
Dale Purves et al.
Introduces the nervous system through converging evidence from anatomy, physiology and behaviour rather than any one method, aimed at readers new to the field.
The wiring diagram, at the level we currently have it.
10 topics · 19 curated works
No prior grounding assumed.
Neuroscience
Dale Purves et al. · 1997
Introduces the nervous system through converging evidence from anatomy, physiology and behaviour rather than any one method, aimed at readers new to…
Assumes you know the vocabulary.
The Triune Brain in Evolution
Paul MacLean · 1990
Argues the human brain evolved in three successive anatomical layers - reptilian, limbic and neocortical - a model since undermined by comparative…
+6 more at this level
Primary sources and full treatments.
The Integrative Action of the Nervous System
Charles Sherrington · 1906
Argues the nervous system's basic unit of function is the reflex arc, and builds an account of integration in which reflexes combine, inhibit and…
+10 more at this level
12 of 19 works
Dale Purves et al.
Introduces the nervous system through converging evidence from anatomy, physiology and behaviour rather than any one method, aimed at readers new to the field.
Paul MacLean
Argues the human brain evolved in three successive anatomical layers - reptilian, limbic and neocortical - a model since undermined by comparative neuroanatomy showing no such discrete evolutionary strata.
Jonathan Horton & Daniel Adams
Reviews the anatomical evidence for cortical columns and concludes most species show no sharp modular boundaries, challenging the column as a general organising principle.
link checked 17 Sept 2026Clifford Saper, Thomas Scammell & Jun Lu
Argues sleep and wake are produced by a mutually inhibitory switch between hypothalamic and brainstem nuclei rather than by any single sleep or wake centre.
Sten Grillner
Argues locomotion is generated by spinal central pattern generators whose basic rhythm-producing logic is conserved from lamprey to mammal.
Ann Graybiel
Argues the basal ganglia encode habits as chunked action sequences evaluated by dopamine signals, linking habitual behaviour to a specific circuit mechanism.
link checked 17 Sept 2026Van Wedeen et al.
Claims diffusion imaging shows brain fibre pathways form a simple three-dimensional grid, a finding subsequently disputed by tractography studies that found no such universal structure.
link checked 17 Sept 2026S. Murray Sherman
Argues the thalamus continuously shapes ongoing cortical computation rather than merely relaying sensory input on its way up to cortex.
link checked 17 Sept 2026Charles Sherrington
Argues the nervous system's basic unit of function is the reflex arc, and builds an account of integration in which reflexes combine, inhibit and facilitate one another.
link checked 17 Sept 2026James Papez
Proposes a closed anatomical circuit running from hippocampus through hypothalamus and thalamus to cingulate cortex as the substrate of emotional experience.
Giuseppe Moruzzi & Horace Magoun
Shows that stimulating the brainstem reticular formation activates the cortical EEG independent of specific sensory pathways, establishing a distinct arousal system.
David Marr
Proposes that climbing fibres teach Purkinje cells which parallel-fibre patterns to weaken, giving the cerebellar cortex a concrete synaptic learning rule for motor skill.
link checked 17 Sept 2026