Biology at the scale where you need a computer to read the data.
12 topics · 12 curated works
Assumes you know the vocabulary.
The Sequence Alignment/Map Format and SAMtools
Heng Li et al. · 2009
Defines the SAM/BAM format and the toolkit for storing and querying aligned sequencing reads, the shared substrate nearly every genomics pipeline has…
+2 more at this level
Primary sources and full treatments.
Principles that Govern the Folding of Protein Chains
Christian B. Anfinsen · 1973
Argues that a protein's amino acid sequence alone determines its folded three-dimensional shape, which implies structure should in principle be…
+8 more at this level
12 works
Heng Li et al.
Defines the SAM/BAM format and the toolkit for storing and querying aligned sequencing reads, the shared substrate nearly every genomics pipeline has been built on since.
link checked 17 Sept 2026Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz & Koichiro Tamura
Documents the software most working biologists actually use to build and test evolutionary trees from sequence data, spanning alignment, model selection and tree inference in one package.
link checked 17 Sept 2026The UniProt Consortium
Documents the single most-used reference database of protein sequence and function, arguing a shared, continuously curated resource beats every lab maintaining its own private annotations.
link checked 17 Sept 2026Christian B. Anfinsen
Argues that a protein's amino acid sequence alone determines its folded three-dimensional shape, which implies structure should in principle be computable from sequence.
link checked 17 Sept 2026Frederick Sanger, Steve Nicklen & Alan R. Coulson
Introduces the chain-termination method for reading a DNA sequence base by base, the technique that made routine genome sequencing possible.
link checked 17 Sept 2026Lincoln D. Stein et al.
Sequences a second nematode genome specifically to compare against C. elegans, using the divergence between the two species to pick out which genome sequences are under selection and therefore functional.
link checked 17 Sept 2026Lyris M. F. de Godoy et al.
Uses stable-isotope labelling to quantify nearly the entire yeast proteome by mass spectrometry, arguing near-complete proteome coverage was already achievable if the workflow was designed carefully enough.
link checked 17 Sept 2026Wellcome Trust Case Control Consortium
Scans genetic variation across the whole genome in thousands of patients and controls at once, establishing genome-wide association studies as a practical way to find disease-linked variants without a prior hypothesis about which gene to check.
link checked 17 Sept 2026Manfred G. Grabherr et al.
Introduces Trinity, an algorithm that reconstructs full-length transcripts directly from short sequencing reads, making transcriptome analysis possible for the vast majority of species that have no reference genome at all.
link checked 17 Sept 2026Kyle J. Travaglini et al.
Profiles tens of thousands of individual lung cells to build a reference atlas of every cell type in the human lung, including several rare cell types no prior study had characterised.
link checked 17 Sept 2026John Jumper et al.
Shows a deep learning system can predict protein structure from sequence at an accuracy rivalling experimental methods, closing a fifty-year-old open problem in structural biology.
link checked 17 Sept 2026Stephen Nayfach et al.
Mines thousands of gut metagenomes to assemble the largest catalogue yet of the viruses that live among our gut bacteria, most of them previously undescribed.
link checked 17 Sept 2026This subject genuinely sits in more than one domain. These fields approach the same ground with different methods.