How information is stored, copied and expressed.
14 topics · 14 curated works
No prior grounding assumed.
Experiments in Plant-Hybridisation
Gregor Mendel · 1866
Pea-plant crosses show inherited traits are governed by discrete paired factors that segregate independently, not a continuous blend of parental…
Assumes you know the vocabulary.
RegulonDB (version 5.0): Escherichia coli K-12 Transcriptional Regulatory Network, Operon Organization, and Growth Conditions
Heladia Salgado et al. · 2006
Curates every known transcription factor, operon and regulatory interaction in E. coli into one queryable network, turning decades of scattered…
+2 more at this level
Primary sources and full treatments.
The Genetical Theory of Natural Selection
Ronald A. Fisher · 1930
Builds a mathematical account of how selection changes allele frequencies in populations, arguing Mendelian inheritance, far from undermining…
+9 more at this level
12 of 14 works
Gregor Mendel
Pea-plant crosses show inherited traits are governed by discrete paired factors that segregate independently, not a continuous blend of parental characters.
44 pageslink failing as of 17 Sept 2026Heladia Salgado et al.
Curates every known transcription factor, operon and regulatory interaction in E. coli into one queryable network, turning decades of scattered gene-regulation findings into a single map.
link checked 17 Sept 2026Steve Horvath
Builds a clock from methylation levels at a few hundred genomic sites that predicts a tissue's chronological age across almost the whole body, proposing methylation drift as a measurable signature of ageing.
link checked 17 Sept 2026Barbara Imperiali and Adam Martin (MIT OpenCourseWare)
Presents molecular biology as chemistry acting under selection, running from macromolecular structure through genetics to gene regulation and modern genomic technique.
link checked 17 Sept 2026Ronald A. Fisher
Builds a mathematical account of how selection changes allele frequencies in populations, arguing Mendelian inheritance, far from undermining Darwinism, is exactly what natural selection requires to work.
link checked 17 Sept 2026Matthew Meselson & Franklin Stahl
Density-labelled DNA shows replication is semiconservative, with each daughter molecule carrying one old and one new strand, settling a question Watson and Crick had only guessed at.
link checked 17 Sept 2026Marshall Nirenberg & J. Heinrich Matthaei
Shows a synthetic RNA of only one repeating base directs a cell-free system to make a protein of only one repeating amino acid, opening the door to cracking the genetic code codon by codon.
link checked 17 Sept 2026Stanley Cohen, Annie Chang, Herbert Boyer & Robert Helling
Shows that DNA fragments from different organisms can be spliced into a plasmid and replicated in bacteria, demonstrating recombinant DNA technology as a working technique for the first time.
link checked 17 Sept 2026David Melzer et al.
Scans the genome against blood protein levels rather than disease status, showing that much of the variation in a protein's abundance is itself a heritable, mappable trait.
link checked 17 Sept 2026Rajnish A. Gupta et al.
Shows a long non-coding RNA transcribed from one gene cluster can travel in trans to reposition a chromatin-modifying complex across the genome, and that this alone is enough to make breast cancer cells more invasive.
link checked 17 Sept 2026Martin Jinek et al.
Shows that the bacterial CRISPR-Cas9 system can be reprogrammed with a single guide RNA to cut any targeted DNA sequence, turning a bacterial immune defence into a general genome-editing tool.
link checked 17 Sept 2026Sarah Djebali et al.
ENCODE RNA sequencing across many cell types shows most of the human genome is transcribed at some point, far beyond the roughly 2% that codes for protein.
link checked 17 Sept 2026This subject genuinely sits in more than one domain. These fields approach the same ground with different methods.